Hydro-Ethanolic Fruit Extract of Capsicum frutescens Reversed Triton-X-100-Induced Hyperlipidaemia in Rats.
Nurudeen S AdigunA Temidayo OladijiTaofeek Olakunle AjiboyePublished in: Journal of dietary supplements (2018)
This study evaluates the anti-hyperlipidaemic and antioxidant activities of hydro-ethanolic fruits extract of Capsicum frutescens in hyperlipidemia rats. The secondary volatile metabolite constituents of the extract were identified using Gas chromatography. In vitro antioxidant activity of the extract (0.2-1.0 mg/mL) was investigated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) and hydroxyl radical (OH.). In vivo antioxidant and anti-hyperlipidaemic properties of the extract were evaluated in triton X-100-induced hyperlipidaemic rats. Gas chromatogram indicates the presence of 13 compounds with tans β-ocimene being the major constituent. The extract scavenged DPPH, H2O2 and OH. radicals in concentrations dependent manner. C. frutescens reversed triton X-100-mediated increase in serum total cholesterol, triglycerides and low-density lipoprotein, and reduction in high-density lipoprotein. Triton X-100-mediated decrease in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phospahte dehydrogenase were significantly reversed by the extract. The results indicate that C. frutescens has antioxidant and anti-hyperlipidaemic properties.
Keyphrases
- oxidative stress
- anti inflammatory
- hydrogen peroxide
- low density lipoprotein
- diabetic rats
- high density
- gas chromatography
- nitric oxide
- mass spectrometry
- high glucose
- high fat diet
- adipose tissue
- metabolic syndrome
- endothelial cells
- blood glucose
- weight loss
- high speed
- high resolution mass spectrometry
- high fat diet induced
- simultaneous determination