Mortality in children with complicated severe acute malnutrition is related to intestinal and systemic inflammation: an observational cohort study.
Suzanna AttiaChristian J VerslootWieger VoskuijlSara J van VlietValeria Di GiovanniLing ZhangSusan RichardsonCeline BourdonMihai M NeteaJames Alexander BerkleyPatrick F van RheenenRobert H J BandsmaPublished in: The American journal of clinical nutrition (2016)
Diarrhea, high intestinal inflammation, low concentrations of fecal SCFAs, and high systemic inflammation are significantly related to mortality in SAM. However, these relations were not mediated by the presence of intestinal pathogens. These findings offer an important understanding of inflammatory changes in SAM, which may lead to improved therapies. This trial was registered at www.controlled-trials.com as ISRCTN13916953.