Therapeutic potential of anti-VEGF receptor 2 therapy targeting for M2-tumor-associated macrophages in colorectal cancer.
Aung Kyi Thar MinKousaku MimuraShotaro NakajimaHirokazu OkayamaKatsuharu SaitoWataru SakamotoShotaro FujitaHisahito EndoMotonobu SaitoZenichiro SazeTomoyuki MommaShinji OhkiKoji KonoPublished in: Cancer immunology, immunotherapy : CII (2020)
Our results suggest that anti-VEGFR2 therapy may have therapeutic potential to control the immune inhibitory functions of M2-TAMs in CRC, resulting in enhanced efficacy of immunotherapy with ICIs.