Aspartame Intake Delayed Puberty Onset in Female Offspring Rats and Girls.

Chia-Yuan LinNam Nhat NguyenWan-Ling TsaiRong-Hong HsiehHung-Tsung WuYang Ching Chen

Published in: Molecular nutrition & food research (2024)

aspartame-fed female offspring delays pubertal onset through the dysregulation of HPG axis and GM composition by inhibiting the Kiss1/GPR54 system and inducing the RFRP-3. An acceptable dose of aspartame should be recommended during childhood.

Keyphrases

high fat diet
signaling pathway
type diabetes
insulin resistance
early life
body mass index