Identification of the First Sulfobetaine Hydrogel-Binding Peptides via Phage Display Assay.

Using the M13 phage display a series of 7-mer and 12-mer peptides which interact with new sulfobetaine hydrogels (J. Phys. Chem. B, 2021, 125, 13, 3398-3408) were identified. Two peptides each from the 7-mer and 12-mer peptide libraries bind to the new sulfobetaine hydrogels with high affinity compared to the wild-type phage lacking a dedicated binding peptides. This is the first report of peptides binding to zwitterionic sulfobetaine hydrogels and the study therefore opens up the pathway towards new phage or peptide/hydrogel hybrids with high application potential. This article is protected by copyright. All rights reserved.