In vitro and In vivo Activity of a New N-Oxide Derivative for Acne Vulgaris Treatment.
Ivone Leila Lima DelgadoCauê Benito ScarimFelipe Hugo Alencar FernandesKarina Pereira BarbieriMarisa Campos PolesiAline Renata PavanDiego Eidy ChibaHérida Regina Nunes SalgadoIracilda Zeppone CarlosMarcos Antonio CorrêaCleverton Roberto de AndradeJean Leandro Dos SantosPublished in: Medicinal chemistry (Shariqah (United Arab Emirates)) (2024)
Similar results were observed in the benzoyl peroxide group, demonstrating that compound 15 presented comparable anti-inflammatory activity to the FDA-approved drug. These promising results suggest that compound 15 has a dual mechanism of action, with selective antimicrobial activity against C. acnes and notable anti-inflammatory properties, making it a potential prototype for developing new treatments for acne vulgaris.