Murine model of left ventricular diastolic dysfunction and electro-mechanical uncoupling following high-fat diet.
Serena L'AbbateNicole Di LascioGiuseppina NicoliniFrancesca ForiniFrancesco FaitaClaudia KusmicPublished in: International journal of obesity (2005) (2019)
The described murine model of 13 weeks on HF diet, well reproduced the cardiovascular and metabolic disorders reported in clinical obesity, suggesting its potential utility as translational mean suitable for testing new pharmaco-therapeutic approaches to the treatment of obesity and its comorbidity.
Keyphrases
- high fat diet
- insulin resistance
- left ventricular
- weight loss
- metabolic syndrome
- adipose tissue
- high fat diet induced
- type diabetes
- skeletal muscle
- heart failure
- physical activity
- acute myocardial infarction
- hypertrophic cardiomyopathy
- blood pressure
- oxidative stress
- cardiac resynchronization therapy
- aortic stenosis
- left atrial
- ejection fraction
- percutaneous coronary intervention
- acute coronary syndrome
- transcatheter aortic valve replacement
- acute heart failure
- gestational age
- mass spectrometry