Anaplastic large cell lymphoma in a pregnant Filipino woman successfully treated with prepartum and postpartum chemotherapy.
Madelaine Amurao AmanteSharon Jane Pingol GalagnaraJorge IgnacioPublished in: BMJ case reports (2018)
Diagnosis of a malignancy during pregnancy presents a dilemma regarding the work-up and treatment of the patient. This report presents a 42-year-old woman on her 23rd week of pregnancy with multiple enlarging fungating violaceous skin masses. Biopsy of the dominant mass revealed anaplastic large cell lymphoma. Due to the progressive enlargement and increase in number of the masses, the patient was given two cycles of chemotherapy (doxorubicin, vincristine, cyclophosphamide and prednisone) before delivering a live baby boy via spontaneous vaginal delivery, Apgar 9.9, at 37 4/7 weeks. After delivery, she completed four more cycles of treatment. A full-body positron emission tomography scan done 2 months after the last chemotherapy showed no evidence of disease. The patient is doing well with no evidence of disease 9 months after treatment. Her baby is thriving and has no gross deformities and no developmental delays.
Keyphrases
- positron emission tomography
- computed tomography
- case report
- single cell
- locally advanced
- diffuse large b cell lymphoma
- cell therapy
- ultrasound guided
- multiple sclerosis
- pregnant women
- squamous cell carcinoma
- low dose
- drug delivery
- magnetic resonance imaging
- preterm birth
- pet ct
- contrast enhanced
- clinical trial
- magnetic resonance
- combination therapy
- cancer therapy
- bone marrow
- double blind