Serial changes in renal indices in chronic HCV patients with and without HIV co-infection receiving sofosbuvir and tenofovir-based therapies.
Shereen Abdel AlemNaeema El GarhyEngy El KhateebMahmoud KhalilAhmed CordieAisha ElsharkawyRabab FouadGamal EsmatMohammad Salah AbdelbaryPublished in: Transactions of the Royal Society of Tropical Medicine and Hygiene (2022)
Because the changes in eGFR were minimal and not of clinical significance, and TDF was not associated with an increase in renal dysfunction, SOF-based direct-acting antivirals could be safely used in HCV mono-infected and HCV-HIV individuals, even in those on TDF-based ART.