Proinflammatory and regulatory mechanisms in allergic contact dermatitis caused by methylchloroisothiazolinone and methylisothiazolinone.
Heliana Freitas de Oliveira GoesAnangelica Rodrigues VirgensGabriel Costa de CarvalhoAnna Julia PietrobonAnna Cláudia Calvielli Castelo BrancoLuanda Mara da Silva OliveiraIara G FernandesNaiura Vieira PereiraMírian Nacagami SottoVitor Manoel Silva Dos ReisMaria Notomi SatoPublished in: Experimental dermatology (2020)
Considering the altered innate immune response triggered by MCI/MI sensitization, these findings indicate that the regulatory process at the induction phase of ACD is a crucial mechanism. Given the increase in occupational and domestic exposure to MCI/MI, the underlying immunological mechanisms should be understood.