New targeted approaches for epigenetic age predictions.

Yang HanJulia FranzenThomas StiehlMichael GobsChao-Chung KuoMiloš NikolićJan HapalaBarbara Elisabeth KoopKlaus StrathmannStefanie Ritz-TimmeWolfgang Wagner

Published in: BMC biology (2020)

Targeted DNA methylation analysis at few age-associated CpGs by pyrosequencing, BBA-seq, and particularly ddPCR enables high precision of epigenetic age-predictions. Furthermore, we demonstrate that the stochastic evolution of age-associated DNA methylation patterns in BBA-seq data enables epigenetic clocks for individual DNA strands.

Keyphrases

dna methylation
genome wide
gene expression
cancer therapy
rna seq
copy number
machine learning
artificial intelligence
big data
data analysis