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Beta-adrenergic blockade increases pulmonary vascular resistance and causes exaggerated hypoxic pulmonary vasoconstriction at high altitude: a physiological study.

Matthias Peter HiltyChristoph SiebenmannPeter RasmussenStefanie KeiserAndrea MüllerCarsten LundbyMarco Maggiorini
Published in: European heart journal. Cardiovascular pharmacotherapy (2024)
Our data show that β-adrenergic blockade increases, and muscarinic blockade decreases PVR, whereas both increase pulmonary artery elastance. Future studies may confirm potential implications from the finding that β-adrenergic blockade exaggerates HPV for the management of mountaineers using β-blockers for prevention or treatment of cardiovascular conditions.
Keyphrases
  • pulmonary artery
  • pulmonary hypertension
  • coronary artery
  • pulmonary arterial hypertension
  • high grade
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