Preliminary Study of Whole-Genome Bisulfite Sequencing and Transcriptome Sequencing in VHL Disease-Associated ccRCC.

Lei LiHainan BaoYawei XuWuping YangZedan ZhangKaifang MaKenan ZhangJingcheng ZhouYanqing GongWeimin CiKan Gong

Published in: Molecular diagnosis & therapy (2023)

Our study mapped the multiomics of copy number variation, methylation and mRNA level changes in tumor and normal tissues of clear cell renal cell carcinoma with VHL syndrome, which provides a solid foundation for the mechanistic study, biomarker screening, and therapeutic target discovery of clear cell renal cell carcinoma.

Keyphrases

copy number
genome wide
single cell
gene expression
mitochondrial dna
dna methylation
small molecule