Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor.
Qiaojun QuZeyu ZhangXiaoyong GuoJunying YangCaiguang CaoChangjian LiHui ZhangPengfei XuZhenhua HuZhenyu ZhangPublished in: Journal of nanobiotechnology (2022)
Incomplete tumor resection is the direct cause of the tumor recurrence and metastasis after surgery. Intraoperative accurate detection and elimination of microscopic residual cancer improve surgery outcomes. In this study, a powerful D1-π-A-D2-R type phototheranostic based on aggregation-induced emission (AIE)-active the second near-infrared window (NIR-II) fluorophore is designed and constructed. The prepared theranostic agent, A1 nanoparticles (NPs), simultaneously shows high absolute quantum yield (1.23%), excellent photothermal conversion efficiency (55.3%), high molar absorption coefficient and moderate singlet oxygen generation performance. In vivo experiments indicate that NIR-II fluorescence imaging of A1 NPs precisely detect microscopic residual tumor (2 mm in diameter) in the tumor bed and metastatic lymph nodes. More notably, a novel integrated strategy that achieves complete tumor eradication (no local recurrence and metastasis after surgery) is proposed. In summary, A1 NPs possess superior imaging and treatment performance, and can detect and eliminate residual tumor lesions intraoperatively. This work provides a promising technique for future clinical applications achieving improved surgical outcomes.
Keyphrases
- fluorescence imaging
- photodynamic therapy
- lymph node
- drug delivery
- small cell lung cancer
- minimally invasive
- metabolic syndrome
- type diabetes
- drug release
- computed tomography
- patients undergoing
- coronary artery disease
- early stage
- acute coronary syndrome
- molecular dynamics
- rectal cancer
- quantum dots
- neoadjuvant chemotherapy
- energy transfer
- surgical site infection