Feasibility of a Pragmatic PBPK Modeling Approach: Towards Model-Informed Dosing in Pediatric Clinical Care.
Joyce E M van der HeijdenJolien J M FreriksenMarika A de Hoop-SommenLianne P M van BusselSander H P DriessenAnne E M OrlebekeLaurens F M VerscheijdenRick GreupinkSaskia N de WildtPublished in: Clinical pharmacokinetics (2022)
Pragmatic PBPK modeling in pediatrics, based on compound models verified with adult data, is feasible. A thorough understanding of the model assumptions and limitations is required, before model-informed doses can be recommended for clinical use.