Control of S phase duration: a replication capacity model with E2F transcription at its heart.
Cosetta BertoliRobertus A M de BruinPublished in: Molecular & cellular oncology (2021)
DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication.