Scalp EEG spikes predict impending epilepsy in TSC infants: A longitudinal observational study.
Joyce Y WuMonisha GoyalJurriaan M PetersDarcy KruegerMustafa SahinHope NorthrupKit S AuSarah O'KelleyMarian WilliamsDeborah A PearsonEllen HansonAnna W ByarsJessica KreftingMark BeasleyGary CutterNita LimdiJurriaan M PetersPublished in: Epilepsia (2019)
IEDs identify impending epilepsy in the majority (77%) of seizure-naive infants with TSC. The use of a 1-hour awake and asleep EEG can be used as a biomarker for ongoing epileptogenesis in most, but not all, infants with TSC. Persistent seizures, but not history of interictal epileptiform activity or history of well-controlled seizures, correlated with low scores on the Vineland and Mullen tests at 2 years of age.