Pre-clinical investigation of the synergy effect of interleukin-12 gene-electro-transfer during partially irreversible electropermeabilization against melanoma.

Lise PasquetElisabeth BellardSophie ChabotBostjan MarkelcMarie-Pierre RolsJustin TeissieMuriel Golzio

Published in: Journal for immunotherapy of cancer (2019)

The combination of pIL-12 GET and pIRE not only enhanced survival but could bring a curative effect in wild type mice. This two-step treatment, named Immune-Gene Electro-Therapy (IGET), led to a systemic activation of the adaptive immune system and the development of an anti-tumor immune memory.

Keyphrases

wild type
genome wide
copy number
high speed
genome wide identification
stem cells
type diabetes
rectal cancer
adipose tissue
metabolic syndrome
dna methylation
transcription factor
cell therapy
skin cancer
high resolution
insulin resistance
mass spectrometry