Spiperone Stimulates Regeneration in Pulmonary Endothelium Damaged by Cigarette Smoke and Lipopolysaccharide.

Evgenii SkurikhinOlga Victorovna Pershina Mariia Zhukova Darius Widera Edgar PanAngelina PakhomovaVyacheslav KrupinNatalia Nicolaevna ErmakovaVictoria SkurikhinaLubov SandrikinaSergey MorozovAslan KubatievAlexander Dygai

Published in: International journal of chronic obstructive pulmonary disease (2021)

Overall, our results suggest that spiperone mediates endothelial regeneration in an animal model of COPD. Thus, it could represent a novel therapeutic approach for treatment of emphysema associated with COPD.

Keyphrases

chronic obstructive pulmonary disease
lung function
stem cells
pulmonary hypertension
nitric oxide
toll like receptor
cystic fibrosis
air pollution
wound healing
immune response
replacement therapy