Bacteriophage Therapy of Multidrug-Resistant Achromobacter in an 11-year-old Boy With Cystic Fibrosis Assessed by Metagenome Analysis.

Bacteriophage/antibiotic treatment decreased the host pulmonary bacterial burden for Achromobacter assessed by metagenome analysis of sputum and blood, with ongoing bacteriophage replication documented in sputum at 1-month follow-up. Prospective controlled studies are needed to define the dose, route of administration and duration of bacteriophage therapy for both acute and chronic infection in CF.