The influence of HLA genotype on the development of metal hypersensitivity following joint replacement.
David J LangtonRohan M BhalekarThomas J JoyceStephen P RushtonBenjamin J WainwrightMatthew E NargolNish ShyamBenedicte A LieMoreica B PabbruweAlan J StewartSusan WallerShonali NatuRenne RenRachelle HornickRebecca DarlayEdwin P SuAntoni V F NargolPublished in: Communications medicine (2022)
The development of DTH following joint replacement appears to be determined by the interaction between implant wear and a patient's genotype. The algorithm described in this paper may improve implant selection and help direct patient surveillance following surgery. Further consideration should be given towards understanding patient-specific responses to different biomaterials.