Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease.
Ornella V BilletteGabriel ZieglerMerita AruciHartmut SchützeJasmin M KizilirmakAnni RichterSlawek AltensteinClaudia BartelsFrederic BrosseronArturo Cardenas-BlancoPhilip DahmenPeter DechentLaura DobischKlaus FliessbachSilka Dawn FreieslebenWenzel GlanzDoreen GöerßJohn Dylan HaynesMichael T HenekaIngo KilimannOkka KimmichLuca KleineidamChristoph LaskeAndrea LohseAyda RostamzadehCoraline MetzgerMatthias H MunkOliver PetersLukas PreisJosef PrillerKlaus SchefflerAnja SchneiderAnnika SpottkeEike Jakob SpruthAlfredo RamirezSandra RöskeNina RoyStefan TeipelMichael WagnerJens WiltfangSteffen WolfsgruberRenat YakupovPeter ZeidmanFrank JessenBjörn Hendrik SchottEmrah DüzelAnne Maassnull nullPublished in: Neurology (2022)
Novelty-related activity in the precuneus follows a nonlinear pattern across the clinical spectrum of increased AD risk. Although the underlying mechanism remains unclear, increased precuneus activity might represent an early signature of memory impairment. Our results highlight the nonlinearity of activity alterations that should be considered in clinical trials using functional outcome measures or targeting hyperactivity.