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Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data: a multi-phased study of prostate cancer.

Chong WuJingjing ZhuAustin KingXiaoran TongQing LuJong Y ParkLiang WangGuimin GaoHong-Wen DengYaohua YangKaren E KnudsenTimothy R RebbeckJirong LongWei ZhengWei PanDavid V ContiChristopher A HaimanLang Wu
Published in: Cancer communications (London, England) (2021)
We developed and validated a new PRS which may improve the utility in predicting the risk of developing PCa. Our innovative method can also be applied to other human diseases to improve risk prediction across multiple outcomes.
Keyphrases
  • dna methylation
  • gene expression
  • prostate cancer
  • endothelial cells
  • genome wide
  • radical prostatectomy
  • electronic health record
  • big data
  • adipose tissue
  • machine learning
  • deep learning
  • weight loss