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Differential Methylation in APOE (Chr19; Exon Four; from 44,909,188 to 44,909,373/hg38) and Increased Apolipoprotein E Plasma Levels in Subjects with Mild Cognitive Impairment.

Oscar Mancera-PáezKelly Estrada-OrozcoMaría Fernanda MahechaFrancy CruzKely Bonilla-VargasNicolás SandovalEsneyder GuerreroDavid Salcedo-TacumaJesús D MelgarejoEdwin VegaJenny Ortega-RojasGustavo C RománRodrigo Pardo-TurriagoHumberto Arboleda
Published in: International journal of molecular sciences (2019)
Differential APOE methylation and increased plasma ApoE levels were correlated with MCI. These epigenetic patterns require confirmation in larger samples but could potentially be used as biomarkers to identify early stages of MCI.
Keyphrases
  • mild cognitive impairment
  • cognitive decline
  • dna methylation
  • genome wide
  • gene expression
  • high fat diet
  • type diabetes
  • fluorescent probe
  • insulin resistance
  • living cells