Mid-dose losartan mitigates diabetes-induced hepatic damage by regulating iNOS, eNOS, VEGF, and NF-κB expressions
Fatih OltuluAylin BuhurÇevik GürelGökçe Cerren KuşçuMelih DagdevirenNefise Ülkü Karabay YavaşoğluTimur KoseAltug YavasogluPublished in: Turkish journal of medical sciences (2019)
This study indicated that mid-dose losartan administration may have a therapeutic effect by inhibiting apoptosis and regulating iNOS, eNOS, VEGF, and NF-κB protein expressions in DM-induced hepatic damage.
Keyphrases
- oxidative stress
- endothelial cells
- high glucose
- pi k akt
- diabetic rats
- nitric oxide synthase
- signaling pathway
- vascular endothelial growth factor
- cell cycle arrest
- type diabetes
- lps induced
- nitric oxide
- angiotensin ii
- cardiovascular disease
- drug induced
- glycemic control
- nuclear factor
- endoplasmic reticulum stress
- cell death
- cell proliferation
- adipose tissue
- metabolic syndrome
- radiation induced
- amino acid
- toll like receptor