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Contribution of maternal mosaicism to false-positive chromosome X loss associated with noninvasive prenatal testing.

Junhui WanRu LiFatao LiQiuxia YuDan WangXiuhong SunYongling ZhangXiangyi JingXuewei TangGuilan ChenFan JiangFucheng LiFang FuYan LiLina ZhangCuixing YiJian LiDongzhi LiCan Liao
Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2022)
Our findings indicated that maternal mosaicism of sex chromosome was not uncommon in false-positive NIPT chromosome X loss cases. We recommend that this information should be disclosed to pregnancies during clinical counseling and maternal sex chromosome status should be confirmed for the cases with NIPT chromosome X loss.
Keyphrases
  • copy number
  • pregnancy outcomes
  • birth weight
  • pregnant women
  • healthcare
  • gestational age
  • physical activity
  • gene expression
  • weight gain
  • hiv infected
  • hiv testing
  • men who have sex with men