REM sleep is reduced in late middle-aged and older APOE4 allele carriers.
Claire AndréMarie-Ève Martineau-DussaultAndrée-Ann BarilNicola Andrea MarchiVéronique DaneaultDominique LorrainCarol HudonCélyne H BastienDominique PetitCynthia ThompsonJudes PoirierJacques MontplaisirNadia GosselinJulie CarrierPublished in: Sleep (2024)
Our results show that APOE4 carriers exhibit lower REM sleep duration, including in cognitively unimpaired individuals, possibly resulting from early neurodegenerative processes in regions involved in REM sleep generation and maintenance.