Identification and characterization of vilazodone metabolites in rats and microsomes by ultrahigh-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry.
Balasaheb B ChavanPradipbhai D KalariyaShristy TiwariRakesh D NimbalkarPrabha GargR SrinivasM V N Kumar TalluriPublished in: Rapid communications in mass spectrometry : RCM (2018)
The structures of all the 12 metabolites were elucidated by using LC/ESI-MS/MS. The study suggests that vilazodone was metabolized via hydroxylation, dihydroxylation, glucuronidation, oxidative deamination, dealkylation, dehydrogenation and dioxidation. All the metabolites were screened for toxicity using an in silico tool.
Keyphrases
- ms ms
- tandem mass spectrometry
- liquid chromatography
- ultra high performance liquid chromatography
- simultaneous determination
- mass spectrometry
- high performance liquid chromatography
- high resolution mass spectrometry
- gas chromatography
- liquid chromatography tandem mass spectrometry
- solid phase extraction
- high resolution
- oxidative stress
- molecular docking