Methylphenidate treatment increases hippocampal BDNF levels but does not improve memory deficits in hypoxic-ischemic rats.
Patrícia Maidana MiguelBruna Ferrary DenizHeloísa Deola ConfortimWellington de AlmeidaLoise Peres BronauthMilene Cardoso VieiraKarine BertoldiIonara Rodrigues SiqueiraPatrícia Pelufo SilveiraLenir Orlandi PereiraPublished in: Journal of psychopharmacology (Oxford, England) (2020)
The MPH treatment was not able to improve memory deficits resulting from the HI procedure considering a dose of 2.5 mg/kg. Further studies investigating different MPH doses would be necessary to determine a dose-response relationship in this model.