Gastric fundic gland polyposis and cancer development after eradication of Helicobacter pylori in patient with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS).
Koichi OkamotoTomoyuki KawaguchiKaizo KagemotoYoshifumi KidaYasuhiro MitsuiFumika NakamuraKozo YoshikawaMasahiro SogabeYasushi SatoJoji ShuntoYoshimi BandoMitsuo ShimadaTetsuji TakayamaPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024)
A 44-year-old woman with gastric cancer (GC) and fundic gland polyposis (FGPs) was referred to our hospital for further diagnosis and treatment. She successfully underwent eradication therapy for Helicobacter pylori (HP) 6 years ago, but did not exhibit FGPs at that time. When she underwent an esophagogastroduodenoscopy 2, 4, and 5 years after the eradication of HP, her imaging results revealed the existence of FGPs which gradually increased in her gastric fundus and body. Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) was suspected and a mutational analysis was performed, revealing an APC promoter 1B variant c.-191T > C. A robotic total gastrectomy with lymphadenectomy was performed. Histopathological analysis of the surgical specimens revealed GC with no lymph node metastasis. GAPPS is characterized by GC and FGPs. However, our case shows different gastric phenotypes that are dependent on the status of HP infection.
Keyphrases
- helicobacter pylori
- helicobacter pylori infection
- lymph node metastasis
- papillary thyroid
- squamous cell carcinoma
- chronic rhinosinusitis
- healthcare
- gene expression
- transcription factor
- emergency department
- single cell
- dna methylation
- minimally invasive
- locally advanced
- radiation therapy
- gas chromatography
- diabetic retinopathy
- photodynamic therapy
- squamous cell
- solid phase extraction