Multifunctional Prosthesis Surface: Modification of Titanium with Cinnamaldehyde-Loaded Hierarchical Titanium Dioxide Nanotubes.
Yi MaoXinru XieGuangxin SunShiqi YuMingqi MaRui ChaoTianhao WanWeifeng XuXuzhuo ChenLei SunShanyong ZhangPublished in: Advanced healthcare materials (2024)
Orthopedic prostheses are the ultimate therapeutic solution for various end-stage orthopedic conditions. However, aseptic loosening and pyogenic infections remain as primary complications associated with these devices. In this study, a hierarchical titanium dioxide (TiO 2 ) nanotube drug delivery system loaded with cinnamaldehyde for the surface modification of titanium implants, is constructed. These specially designed dual-layer TiO 2 nanotubes enhance material reactivity and provide an extensive drug-loading platform within a short time. The introduction of cinnamaldehyde enhances the bone integration performance of the scaffold (simultaneously promoting bone formation and inhibiting bone resorption), anti-inflammatory capacity, and antibacterial properties. In vitro experiments have demonstrated that this system promoted osteogenesis by upregulating both Wnt/β-catenin and MAPK signaling pathways. Furthermore, it inhibits osteoclast formation, suppresses macrophage-mediated inflammatory responses, and impedes the proliferation of Staphylococcus aureus and Escherichia coli. In vivo experiments shows that this material enhances bone integration in a rat model of femoral defects. In addition, it effectively enhances the antibacterial and anti-inflammatory properties in a subcutaneous implant in a rat model. This study provides a straightforward and highly effective surface modification strategy for orthopedic Ti implants.
Keyphrases
- signaling pathway
- anti inflammatory
- soft tissue
- escherichia coli
- staphylococcus aureus
- drug delivery
- bone loss
- bone mineral density
- cell proliferation
- cancer therapy
- stem cells
- bone regeneration
- wound healing
- high throughput
- risk factors
- silver nanoparticles
- wastewater treatment
- postmenopausal women
- pseudomonas aeruginosa
- electronic health record
- quantum dots
- tissue engineering
- multidrug resistant
- drug induced
- essential oil