ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer.

Pingping SuXiaodan MaoJincheng MaLixiang HuangLirui YuShuting TangMingzhi ZhuangZhonglei LuKelvin Stefan OsafoYuan RenXinrui WangXite LinLeyi HuangXiaoli HuangElena Ioana BraicuJalid SehouliPeng-Ming Sun

Published in: Journal of experimental & clinical cancer research : CR (2023)

ERRα inhibits pyroptosis in an NLRP3-dependent manner and induces glycolytic metabolism, resulting in cisplatin resistance in EC cells.

Keyphrases

endometrial cancer
nlrp inflammasome
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
signaling pathway
oxidative stress
cell proliferation
pi k akt