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Application of network pharmacology and molecular docking to elucidate the potential mechanism of Eucommia ulmoides-Radix Achyranthis Bidentatae against osteoarthritis.

Gong-Hui JianBing-Zhu SuWen-Jia ZhouGonghui Jian
Published in: BioData mining (2020)
Based on network pharmacology and molecular docking analysis, the present study provides insights into the potential mechanism of EU-RAB in osteoarthritis after successfully screening for associated key target genes and signaling pathways. These findings further provide a theoretical basis for further pharmacological research into the potential mechanism of EU-RAB in osteoarthritis.
Keyphrases
  • molecular docking
  • molecular dynamics simulations
  • rheumatoid arthritis
  • knee osteoarthritis
  • human health
  • genome wide
  • gene expression
  • oxidative stress
  • pi k akt