Anomalous glucose-responsive rheological changes in a boronic acid-modified hyaluronan.

Herein, we report anomalous glucose (Glc)-responsive gelation/solation in 3-aminophenylboronic acid-modified hyaluronic acid. With 5-20 mM Glc, gelation occurred, resulting in the formation of crosslinks via Glc, which could reversibly bind to the two boronic acid sites. Solation was induced at Glc concentrations of >80 mM.