Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain.

gene contains a number of rare variants linked with increased and decreased risk for Alzheimer's disease and longevity, but little is known about the role of PLCγ2 in normal brain function. The results described herein are significant because they describe the effects of knockout of PLCγ2 on brain cell types, thus mimicking the loss of function Alzheimer's disease risk mutation. Our data describe novel effects of PLCγ2 deficiency on myelin homeostasis and mTOR signaling that have not been previously described that may underlie its association with Alzheimer's disease pathogenesis and longevity.