Identification and Characterization of a Small Molecule Bcl-2 Functional Converter.

Prasad R Kopparapu Martin C Pearce Christiane V Löhr Cathy Duong Hyo Sang Jang Shanthakumar Tyavanagimatt Edmond F O'Donnell Harikrishna Nakshatri Siva K Kolluri

Published in: Cancer research communications (2024)

We report the identification of a small molecule that exposes the Bcl-2 killer conformation and induces death in Bcl-2-expressing cancer cells. Selective targeting of Bcl-2 and elimination of cancer cells expressing Bcl-2 opens up new therapeutic avenues.

Keyphrases

small molecule
protein protein
wild type