Early Acute Microvascular Kidney Transplant Rejection in the Absence of Anti-HLA Antibodies Is Associated with Preformed IgG Antibodies against Diverse Glomerular Endothelial Cell Antigens.
Marianne DelvilleBaptiste LamarthéeSylvain PagieSarah B SeeMarion RabantCarole BurgerPhilippe GataultMagali GiralOlivier ThaunatNadia ArzoukAlexandre HertigMarc HazzanMarie MatignonChristophe MariatSophie CaillardNassim KamarJohnny SayeghPierre-François WesteelCyril GarrousteMarc LadrièreVincent VuibletJoseph RivalanPierre MervilleDominique BertrandAlain Le MoineJean-Paul Duong Van HuyenAnne CesbronNicolas CagnardOlivier AlibeuSimon C SatchellChristophe LegendreEmmanuel ZornJean-Luc TaupinBéatrice CharreauDany AnglicheauPublished in: Journal of the American Society of Nephrology : JASN (2019)
Our findings indicate that preformed IgG Abs targeting non-HLA antigens expressed on glomerular endothelial cells are associated with early AMVR, and that in vitro cell-based assays are needed to improve risk assessments before transplant.