AIF1 + CSF1R + MSCs, induced by TNF-α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis.
Chen ZongYan MengFei YeXue YangRong LiJinghua JiangQiudong ZhaoLu GaoZhipeng HanLixin WeiPublished in: Hepatology (Baltimore, Md.) (2022)
Together, our results show that MSCs, which are mobilized to the injured site, can be educated by macrophages. In turn, the educated MSCs are involved in generating a chronic inflammatory microenvironment and promoting HCG.