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Budesonide repairs decreased barrier integrity of eosinophilic nasal polyp epithelial cells caused by PM2.5.

Siyuan MaMu XianYang WangChengshuo WangLuo Zhang
Published in: Clinical and translational allergy (2021)
PM2.5 impaired the barrier function of eos-CRSwNP epithelial cells and increased the permeability of large molecules. PM2.5 also increased the secretion of pro-inflammatory cytokines by nasal epithelial cells. Budesonide could partially repair the damage, suggesting potential applications in clinical practice.
Keyphrases
  • particulate matter
  • air pollution
  • chronic rhinosinusitis
  • polycyclic aromatic hydrocarbons
  • clinical practice
  • heavy metals
  • water soluble
  • oxidative stress
  • endothelial cells
  • risk assessment