Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies.

Zilong BianLijuan WangRong FanJing SunLili YuMeihong XuPaul R H J TimmersXia ShenJames F WilsonEvropi TheodoratouXifeng WuXue Li

Published in: BMJ evidence-based medicine (2024)

Genetic and lifestyle factors were independently associated with lifespan. Adherence to healthy lifestyles could largely attenuate the genetic risk of a shorter lifespan or premature death. The optimal combination of healthy lifestyles could convey better benefits for a longer lifespan, regardless of genetic background.

Keyphrases

genome wide
copy number
endothelial cells
metabolic syndrome
type diabetes
physical activity
dna methylation
gene expression
skeletal muscle
glycemic control