Effects of α5 GABA A receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease.

Jovana AranđelovićAnja SantračBojan BatinićLidija TodorovićVladimir StevanovićVeera Venkata Naga Phani Babu TiruveedhulaDishary SharminFarjana RashidBoban StanojevićJames M CookMiroslav M Savić

Published in: CNS neuroscience & therapeutics (2022)

PAM and NAM failed to exert favorable behavioral effects in transgenic animals. Suppression of neuroinflammation obtained with NAM calls for more studies with GABAergic ligands in amyloid beta- and/or tau-dependent models with prominent neuroinflammation.

Keyphrases

lipopolysaccharide induced
lps induced
traumatic brain injury
mouse model
cognitive impairment
cerebral ischemia
inflammatory response
healthcare
cognitive decline
mental health
working memory
cerebrospinal fluid
blood brain barrier
case control