Inhaled glucocorticoid-induced metabolome changes in asthma.

Peter T Daley-YatesBrian KepplerNoushin BrealeyShaila ShabbirDave SinghNeil Barnes

Published in: European journal of endocrinology (2022)

Dose-dependent metabolomic changes occurred with inhaled GCs but were seen predominately at highest/supratherapeutic doses, supporting the safety of low and mid therapeutic doses. At comparable therapeutic doses (FF 100, FP 500 and BUD 800 µg/day), FF had the least effect on the most sensitive markers (adrenal steroids) vs BUD and FP.

Keyphrases

cystic fibrosis
chronic obstructive pulmonary disease
high glucose
lung function
diabetic rats
allergic rhinitis
stress induced