Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury.

Nils Becker Philipp StörmannAndrea JanicovaKernt KöhlerKlemens HorstIldiko Rita DunayClaudia NeunaberIngo MarziJan Tilmann VollrathBorna Relja

Published in: Journal of immunology research (2021)

Since CC16 affects both the distribution of PMNL subsets and apoptosis in tissues after trauma, it may constitute as a novel target to beneficially shape the posttraumatic tissue microenvironment and homeostasis to improving outcomes.

Keyphrases

oxidative stress
stem cells
gene expression
single cell
acute kidney injury
diabetic rats
high glucose
cell therapy
cell death
cell cycle arrest
drug induced
peripheral blood
binding protein
signaling pathway