Nusinersen mitigates neuroinflammation in severe spinal muscular atrophy patients.

Tommaso NuzzoRosita RussoFrancesco ErricoAdele D'AmicoAwet G TeweldeMariangela VallettaAmber HassanMichele TosiChiara PanicucciClaudio BrunoEnrico BertiniAngela ChamberyLivio PellizzoniAlessandro Usiello

Published in: Communications medicine (2023)

These findings highlight signatures of neuroinflammation that are specifically associated with severe SMA and the neuro-immunomodulatory effects of Nusinersen therapy.

Keyphrases

end stage renal disease
traumatic brain injury
ejection fraction
lipopolysaccharide induced
newly diagnosed
early onset
chronic kidney disease
lps induced
cognitive impairment
prognostic factors
stem cells
gene expression
genome wide
inflammatory response
dna methylation
brain injury
bone marrow