Weight loss and abnormal lung inflammation in mice chronically exposed to secondary organic aerosols.
Tanguy DéméautisAlexandra BouyssiAlain GeloenChristian GeorgeJean MenottiOlivier GlehenGilles DevouassouxAbderrazzak BentaherPublished in: Environmental science. Processes & impacts (2023)
Secondary organic aerosols (SOAs) have emerged recently as a major component of fine particulate matter. Cell culture studies revealed a role for SOAs in cell oxidative stress, toxicity and inflammation and only a few studies investigated short-term SOA exposure in animal models. Here, mice were chronically exposed to naphthalene-derived SOAs for one and two months. Weight monitoring indicated a marked mass loss, especially in females, following chronic exposure to SOAs. Significantly, a cytokine antibody microarray approach revealed SOA-induced abnormal lung inflammation similar to that seen in cigarette smoke-induced chronic obstructive pulmonary disease (COPD). This in vivo study testifies to the pathogenic role of sub-chronic SOA exposure on human health.
Keyphrases
- oxidative stress
- diabetic rats
- particulate matter
- chronic obstructive pulmonary disease
- weight loss
- air pollution
- human health
- single cell
- water soluble
- risk assessment
- drug induced
- high glucose
- lung function
- dna damage
- ischemia reperfusion injury
- bariatric surgery
- induced apoptosis
- high fat diet induced
- type diabetes
- roux en y gastric bypass
- body mass index
- stem cells
- atomic force microscopy
- gastric bypass
- body weight
- wild type
- endothelial cells
- single molecule
- bone marrow
- mesenchymal stem cells
- heat stress
- high speed