Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial.
Jelisa GallantKathleen ChanTim J GreenFrank T WieringaShalem LeemaqzRem NgikJeffrey R MeaselleDare A BaldwinMam BorathPrak SophonnearyLisa N YellandDaniela HampelSetareh Shahab-FerdowsLindsay H AllenKerry S JonesAlbert KoulmanDamon A ParkingtonSarah R MeadowsHou KroeunKyly C WhitfieldPublished in: The American journal of clinical nutrition (2021)
A supplemental thiamine dose of 2.35 mg/d was required to achieve a milk total thiamine concentration of 191 µg/L. However, 1.2 mg/d for 22 wk was sufficient to increase milk thiamine concentrations to similar levels achieved by higher supplementation doses (2.4 and 10 mg/d), and comparable to those of healthy mothers in regions without beriberi. This trial was registered at clinicaltrials.gov as NCT03616288.