Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study.
Anders Lund SelliMohammadreza GhasemiTaylor WattersFrancis BurtonGodfrey SmithErik Sveberg DietrichsPublished in: Scandinavian journal of trauma, resuscitation and emergency medicine (2023)
Levosimendan remains a promising candidate drug for inotropic treatment of hypothermic patients as it possesses ability to treat hypothermia-induced cardiac dysfunction and no increased risk of ventricular arrhythmias is detected. Milrinone and isoprenaline, on the other hand, appears more dangerous in the hypothermic setting.
Keyphrases
- cardiac arrest
- end stage renal disease
- endothelial cells
- cardiac surgery
- high glucose
- left ventricular
- ejection fraction
- newly diagnosed
- brain injury
- chronic kidney disease
- heart failure
- peritoneal dialysis
- oxidative stress
- prognostic factors
- diabetic rats
- emergency department
- congenital heart disease
- catheter ablation