Gallium-68-labeled Peptide PET Quantifies Tumor Exposure of PD-L1 Therapeutics.
Akhilesh MishraDhiraj KumarKuldeep GuptaGabriela LoflandAjay Kumar SharmaDhanush S BankaRobert F HobbsRobert F DannalsSteven P RoweEdward GabrielsonSridhar NimmagaddaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
[68Ga]Ga-DK223 detected variable PD-L1 levels and exhibited salient features required for clinical translation. [68Ga]Ga-DK223-PET could be useful for quantifying total PD-L1 levels at baseline and accessible PD-L1 levels during therapy to understand drug exposure at the tumor, thus supporting its use for guiding and optimizing ICT.