Paediatric neuromyelitis optica: clinical, MRI of the brain and prognostic features.

Michael AbsoudMing J LimRichard AppletonAnu JacobJoanna KitleyM Isabel LeiteMichael G PikeAngela VincentEvangeline WassmerPatrick WatersMark WoodhallCheryl HemingwayJacqueline Palace

Published in: Journal of neurology, neurosurgery, and psychiatry (2014)

In children, NMO is associated with early recurrence and visual impairment in AQP4-Ab positivity and physical disability in AP4-Ab negative relapsing cases. Distinct MRI changes appear more commonly and earlier compared to adult NMO. Early AQP4-Ab testing may allow prompt immunomodulatory treatment to minimise disability.

Keyphrases

multiple sclerosis
contrast enhanced
magnetic resonance imaging
white matter
diffusion weighted imaging
young adults
physical activity
emergency department
mental health
transcription factor
computed tomography
disease activity
brain injury
systemic lupus erythematosus
combination therapy
childhood cancer