Elevated plasma hepcidin concentrations are associated with an increased risk of mortality and nonfatal cardiovascular events in patients with type 2 diabetes: a prospective study.
Alessandro MantovaniFabiana BustiNicolò BorellaEnrico ScocciaBarbara PecoraroElena SaniRiccardo MorandinAlessandro CsermelyDaniele PiasentinElisabetta GrespanAnnalisa CastagnaJosh BilsonChristopher D ByrneLuca Vittorio ValentiDomenico GirelliGiovanni TargherPublished in: Cardiovascular diabetology (2024)
In outpatients with T2DM, higher baseline hepcidin concentrations were strongly associated with an increased long-term risk of overall mortality or nonfatal cardiovascular events, even after adjustment for established cardiovascular risk factors, plasma ferritin concentrations, medication use, and other potential confounders.